Electrostatic determinants of stability in parallel 3-stranded coiled coils.
نویسندگان
چکیده
The optimal positioning of salt-bridging interactions in a parallel alpha-helical homotrimeric coiled coil has been explored in a metal ion-assembled polypeptide trimer of 60 residues; arginine-glutamate pairs are more stabilizing than the corresponding lysine-glutamate pairs, and optimal stabilization is obtained with positively charged arginine residues at the c positions of the alpha-helical heptad and negatively charged glutamate residues at the e positions.
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ورودعنوان ژورنال:
- Chemical communications
دوره 2 شماره
صفحات -
تاریخ انتشار 2009